College Football 2021 Top 25 Match-ups And Week 13 Picks



Huge rivalry games top the final weekend of the regular season. FairwayJay chips in more Top 25 college football picks for Week 13 with some major rivalry showdowns impacting the College Football Playoff race. Check out the Top 25 betting report with picks, opinions and information you can bet on.

Preview and Predictions for Week 13 NCAA Top 25 Football Betting and Rivalry Weekend

A few more chip-in winners last Saturday in Week 12, plus a bonus outright underdog winner on Oregon State leads us into the final weekend of the regular season ahead of the big college football conference championship games. And big doesn't describe Thanksgiving weekend in college football, as huge rivalry games take center stage starting with the top-5 monster game at Michigan between the Wolverines and Ohio State Buckeyes. 

This is the biggest betting weekend during the college football season for online sportsbooks. The Thanksgiving holiday combined with NFL, college basketball tournaments and hundreds off added games and the biggest rivalry games in college football brings more fans and recreational bettors on board. 

Let's get right to the Week 13 college football Top 25 match-ups and odds from the leading online sportsbooks, including reduced juice shops. Compare the best spreads and moneylines, and become an OSGA VIP

Week 12 AP Top 25 Match-ups 

Saturday, Nov. 27

No. 2 Ohio State at No. 6 Michigan / 12:00 p.m. ET / FOX
No. 10 Oklahoma at No. 7 Oklahoma State / 7:30 p.m. ET / ABC

Michigan State at Ohio State
Line: Ohio State -8 and Total 64.5 at BetUS

Huge support on Ohio State in 'The Game', yet this line has dipped from the number I bet on Michigan +8.5 to Buckeye's -8, -7.5 and even -7 now at leading online sportsbook BetOnline. The Buckeyes lead the nation in total offense moving up to become a strong, balanced offense averaging 47.2 points and 560 yards per game Michigan Ohio State Rivalry pickat 7.9 yards per play. I don't care that Ohio State has won 15 of the last 16 meetings including 8 in a row with all three wins by double-digits in Ann Arbor. Or as Playbook notes, “Anything you can do, I can do better,” with the Buckeyes bettering Michigan year after year for more than a decade. This year, the Wolverines defense is better, though not elite, and big blue does feature the two leading Big Ten sack artists on defense. Michigan has it's own 200 club offense averaging at least 215 yards per game both rushing and passing. Both teams are top-5 in the College Football Playoff rankings, and so much at stake with a Big Ten East title, entry into the Big Ten Championship Game as a big favorite and a spot in the College Football Playoff awaiting the winner of this game and a follow up victory in the Big Ten Championship Game. Sure Heisman favorite CJ Stroud has the best trio of wide receivers in college football and an elite offensive line that has allowed the fewest sacks in the Big Ten to make him look even better. Let's see how he does in his first game at the Big House in Ann Arbor with 110,000 fans. All the trends favor Ohio State of course, and so many negative ones against Michigan in this one-sided rivalry the past 16 years. Yet just as we predicted in Week 2 with Oregon taking down Ohio State in Columbus, we side with the Michigan men to get the money and no surprise if the Wolverines eat the whole turkey in the biggest and most emotional game of the season. 

Pick: Michigan plus the points and moneyline



Oklahoma at Oklahoma State
Line: Oklahoma State -4 and Total 49.5 at William Hill 

Like the game above, these two teams are also 10-1 and Oklahoma State has been a big moneymaker covering 9-straight games. This has also been a one sided series for nearly two decades with Oklahoma winning 16 of the last 18 meetings. Iron Bowl Oklahoma State Oklahoma predictionThe Cowboys have been fighting for more national respect and higher rankings all season while Oklahoma and freshman QB Caleb Williams has been getting by with some good fortune until getting whacked in Waco by Baylor - another winner on these pages in Week 11. A Baylor win over Texas Tech earlier on Saturday means Oklahoma will need to win the rivalry game over Oklahoma State to set up a rematch in the Big 12 Championship Game on Dec. 4. Oklahoma QB Williams passed for just 146 yards with 2 INTs at Baylor, and the Sooners have been burning money on the road going 0-4 ATS with their lone win away from home on a neutral field against rival Texas. But with the nation's No. 2 scoring defense (14.8 PPG) and No. 1 in sacks and tackles for loss, no team has been able to score more than 24 points on the Cowboys. Oklahoma State Cowboys free pickThe 'Pokes have allowed just one offensive touchdown over their last four games and the Cowboys defense is 127 yards per game better than the Sooners. The Oklahoma State offense has been rolling in recent weeks too with the Cowboy attack rolling up 682 yards against TCU and 535 against Kansas with 400 yards or more in three of the last four games. That moves them to '200 club' status with a perfectly balanced 210 yards per game rushing and passing. Look for the Cowboys to get the better of it in the running game and control play at the point of attack to generate more opportunities and force turnovers. The total has dropped in what has historically been a rivalry shootout favoring the Sooners. Not this year, and we side with Oklahoma State to roll to victory over their rival in Bedlam.  

Pick: Oklahoma State

FairwayJay is a proven sports handicapper and is recognized as one of the sports industry's most insightful analysts. He chips in additional sports betting coverage and reporting on industry news and events. Read more great insights from FairwayJay and follow him on Twitter: @FairwayJay   


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