Things seem to be slipping away for the New Orleans Saints right now. They had to sustain an injury to quarterback Jameis Winston, and even though Trevor Siemian helped save the day against Tampa Bay, they have still lost three games in a row and are just one of a number of teams fighting for wild-card spots at the moment.

Most BetOnline customers might have thought that the Buffalo Bills were going to walk away with the AFC title this season. But suddenly they have lost three of their last five games, and they have actually fallen behind the New England Patriots by a half-game in the division. So they've got some critical business to take care of on Thanksgiving evening.

The Bills and Saints kick things off at 8:20 p.m. Eastern time in at the Superdome, and NBC will televise it.

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It's not just that Buffalo has lost, it's the way that they have lost. They played the Jacksonville Jaguars, one of the lesser teams in the NFL, and couldn't score a touchdown. Last week they were absolutely ripped apart by Jonathan Taylor and the Indianapolis Colts in a 41 –15 beating. Now that they are 6-4, they actually have some catching up to do.

The Saints have dropped these three consecutive games, the first of which came against the Atlanta Falcons at home. Then they went on the road to lose to Tennessee (which was without Derrick Henry) and Philadelphia.

It might be useful to point out that both of these defenses, which have been considered "stout," were shredded on the ground in last week's action.

In the NFL Thanksgiving Day betting odds posted on this contest by the people at BetOnline, the bills are laying points on the road:

Buffalo Bills -6 (-125)
New Orleans Saints + 6 (+105)

Over 44.5 points -112
Under 44.5 points -108

Siemian, who gained his most notoriety as a starter with the Denver Broncos, went through three games without being intercepted, but he wound up succumbing to pressure and was picked off twice by the Philadelphia Eagles. And his yards per attempt of 5.35 was also poor.

Even worse, however, what's the way that New Orleans defended against the run. Granted, Philadelphia is now turning into a rushing juggernaut, but the Saints came into the game as the NFL's best team defending against the run, giving up just 3.1 yards per carry. Needless to say, that figured just didn't hold up, as Philadelphia ran for a season-high 242 yards and simply blew the Saints off the ball.

What becomes problematic for the Saints in this game is that they have glaring absences that you generally can't compensate for. Marcus Davenport is missing from the defensive line. Ryan Ramczyk is not scheduled to play at right tackle, and it'll probably come down to a game-time decision on Terron Armstrong, the tackle on the left side. Adam Trautman, who had been making a lot of progress at the tight end position, catching five passes for 58 yards against Philadelphia, it's now out of action as well.

And of course, Alvin Kamara, one of the elite all-around backs in the NFL, has been ruled out. Mark Ingram is a nice back, and it's a good thing they were able to reacquire him from Houston, as he had 88 yards against the Eagles, but he does not produce in the same way as Kamara.

We may see an awful lot of Taysom Hill, The jack-of-all-trades, who has been underutilized but just signed a four-year contract extension. Obviously that shows Sean Peyton has a lot of faith in him, and he can play in a number of places. Quarterback may not be one of them on Thursday. But tight end might be.

New Orleans won't be able to run the way they want to, and with Siemian — or for that matter Hill — there are certainly limits to where they can go in the passing game. Buffalo seems to get caught sleeping at times, but let's not forget that until last week, Josh Allen and the Bills were tops in the NFL in points per drive, both on the offensive AND defensive sides. They can create a margin here over an opponent that is hobbled. So we will lay the points.

Lots of Turkey Day action at BetOnline, and don't forget, this is blood rivalry week in college football, and you can get the best pointspreads and totals on all the games..... Don't forget you can place wagers on them while they were in progress as well..... And with Odds Boosters, greatly enhanced parlay payouts are there for the taking... To open up an account, you can use your credit card, and any number of cryptocurrency solutions, including, of course, Bitcoin!