NFL Prediction: Buffalo Bills at Arizona Cardinals

A preview of the Bills at Cardinals matchup, with winning angles and a free pick.

Preview and pick for Bills at Cardinals

The Buffalo Bills have shaken off a two-game losing streak against Tennessee and Kansas City with three wins in a row, beating the Jets, Patriots and Seahawks in succession. The win over Seattle was the most impressive, as it pitted division leaders against one another and showed the ferocious power of the Buffalo pass rush.

The Bills blitzed Russell Wilson into mistake after mistake until it was too late for the Seahawk rally to pay off. Next up for the Bills is a trip to the desert to take on the Arizona Cardinals, who had won three in a row until a home loss to the Miami Dolphins last week. Kyler Murray gives the Cardinals a high-octane offense, but the Arizona defense has given up way too much in the last two games.

Can Buffalo get to eight wins in Arizona, or will the Cardinals get the upset?

Buffalo Bills at Arizona Cardinals (Sunday, November 15)
When: Sunday, November 15, 2020, 4:05 pm ET
Where: State Farm Stadium, Glendale, AZ
Radio: WGR 550 AM Buffalo / KMVP 98.7 FM Phoenix
JAZZ Sports Odds: Cardinals -2, Total 56*

Why the Bills Will Win

Buffalo is 3-1 in their last four games away from home, and Josh Allen has gotten back to putting up MVP numbers. He has a 19:5 TD to INT ratio, completing almost 69 percent of his passes for 2,587 yards. In seven of the last nine games, he has thrown for at least two touchdowns. Cole Beasley and Stefon Diggs have Buffalo Bills free pickcaught five touchdown passes combined, picking up 1,346 yards. On the ground, Devin Singletary leads the team with 386 yards and a score.

The Buffalo defense has been banged up for much of the season, but starters have started to make their way back. The team is permitting almost 365 yards and 26 points per game. The pass rush is keyed by Mario Addison's four sacks, and Jordan Poyer is the top tackler on the team with 79.

Why the Cardinals Will Win

Arizona is 3-3 over their last six games and 2-2 in their last four at home. Kyler Murray has a 16:7 TD to INT ratio, with 2,130 yards through the air and a 68.1 percent completion rate. Christian Kirk and DeAndre Hopkins have been the two biggest contributors in the receiving game, scoring nine touchdowns Arizona Buffalo betting tipsand gaining 1,134 yards combined. On the ground, Murray is also the leading rusher, with 543 yards and eight scores.

The Arizona defense permits 22.5 points per game, but that number has grown significantly in the last two games. Haason Reddick leads the team with five sacks, and Jordan Hicks has 66 tackles to pace the Cardinals.

The Final Word

Buffalo gave their season a jumpstart with that big home win over Seattle. Now they come to take on a flawed team that made Tua Tagovailoa look like a seasoned quarterback last week. We like Buffalo to come back from the desert with a tough win.

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