NCAA Tournament 2024 Sweet Sixteen Teams, Matchups and Odds

Time to dance into the Sweet Sixteen, and all the top 1 seeds and three of the 2 seeds remain in the 2025 NCAA Tournament. The top teams in the South and Midwest regions remain with No. 1's Auburn and Houston along with No. 2's Michigan State and Tennessee. The East and West regions still have No. 1's Duke and Florida into the Sweet 16 along with No. 2 Alabama in the East. But St. John's was knocked out of the tournament by No. 10 Arkansas - the highest remaining seed left after No. 12 Colorado State fell to No. 4 Maryland Sunday on a buzzer beater. A pair of No. 3 seeds remain in Kentucky and Texas Tech while No. 4 seeds Arizona, Maryland and Purdue now go to battle against No. 1 seeds in the Sweet Sixteen along with No. 5 seed Michigan.

I’ve chipped in some March Madness Sweet Sixteen coverage in Forbes, and provide the betting lines and TV coverage for March Madness and the biggest betting event of the year for the leading online sportsbooks. The thousands of March Madness contests and bracket pools keep fans more interested and engaged, and especially this year with 9 of the top 12 seeds still alive and just one longshot still in the tournament. 

Sweet Sixteen Matchups, Odds, TV Schedule

College basketball odds from BetOnline and leading online sportsbooks refresh periodically and are subject to change, including on futures, props and live betting. All times Eastern and to be updated along with TV schedule. 

Thursday, March 27 

East - Prudential Center (Newark, NJ) 

- No. 6 BYU vs. No. 2 Alabama (-5)| Total 175.5 | 7:09 p.m. | CBS
- No. 4 Arizona vs. No. 1 Duke (-8.5)| Total 154| 9:39 p.m. | CBS

West - Chase Center (San Francisco, CA) 

- No. 4 Maryland vs. No. 1 Florida (-5.5) | Total 155.5 | 7:39 p.m. | TBS
- No. 10 Arkansas vs. No. 3 Texas Tech (-5.5) | Total 147.5 | 10:09 p.m. | TBS

Friday, March 28 

South - State Farm Arena (Atlanta, GA)

- No. 6 Ole Miss vs. No. 2 Michigan State (-3) | Total 144| 7:09 p.m. | CBS
- No. 5 Michigan vs. No. 1 Auburn (-8.5) | Total 153.5 | 9:39 p.m. | CBS

Midwest - Lucas Oil Stadium, (Indianapolis, IN)

- No. 3 Kentucky vs. No. 2 Tennessee (-4.5) | Total 145 | 7:09 p.m. | TBS
- No. 4 Purdue vs. No. 1 Houston (-8) | Total 133 | 10:39 p.m| TBS

Sweet Sixteen Picks

I've actually bet much less on college basketball during March Madness with limited handicapping through the new year as I traveled and worked as able remotely. Probably a good thing with more favorites continuing to cover and advance in victories with favorites in the opening two rounds 36-12 SU and 26-22 ATS. I did bet underdogs UCONN, Colorado State and New Mexico along with Michigan State/New Mexico under in the Round of 32. Game totals are 20-27-1 over/under with unders cashing more. Additonal college basketball coverage to review including stats and game recaps. 

I'll add a few picks in days ahead for the Sweet 16 and recall a 3-0 result posting here at OSGA in last year's Sweet Sixteen. 

Bet on the Sweet 16 at one of these Elite-rated sportsbooks!

Sweet 16 Betting Trends And Notes

From the Playbook Sports newsletter and research database and other coverage at Gamblers World.

- No. 1 seeds are 25-9 against the spread off back-to-back straight-up (SU) and ATS wins. That includes 7-1 ATS the last 9 years (applies to Duke)
- No. 2 seed favorites are 9-20 ATS, including 1-8 ATS the last 12 years.
- No. 6 seeds are 6-1 ATS the last 11 years.
- No. 10 or worse seed underdogs of more than 4 points are 14-4 ATS last 13 years.
- Underdogs off a SU win of 3 or less points are 13-5-1 ATS the last 12 years.
- Big Ten teams are on a 0-8 ATS run as underdog of more than 3 points, but 5-1 ATS as favorites of more than 2 points.
- ACC favorites or 7 or more points are on a 1-6 ATS run.
- Big 12 teams are on a 1-5 ATS run as underdogs of more than 2 points.

In the 2017 and 2024 NCAA Tournaments, 12 of the top 16 teams seeded by the committee made the Sweet Sixteen. That was the second most since 1997, per the NCAA. This year's 2025 NCAA Tournament again features 12 of the top 16 seeds in the Sweet Sixteen, including all the power conferences. 

7 - SEC
4 - Big Ten
4 - Big 12
1 - ACC 

Odds To Win 2025 NCAA Tournament And Championship

+225: Duke
+400: Florida
+500: Houston
+550: Auburn
+1400: Alabama
+1400: Tennessee
+1800: Texas Tech
+2200: Michigan State
+2800: Maryland
+4000: Arizona
+5000: Kentucky
+6600: Purdue
+6600: Michigan
+8000: Ole Miss
+8000: BYU
+8000: Arkansas 

As noted previously in March Madness coverage, 21 of the last 22 National Champions have finished in the Top 20 in both offensive and defensive adjusted efficiency. Six teams fit the profile and five remain after Iowa State was eliminated. All those top teams are also defensive dominators and top defensive teams.  

Duke (1, 4 off/def)
Florida (2/11)
Auburn (3,12)
Houston (10, 1)
Tennessee (17,3)
Alabama (4,29)
Michigan State (5,25)
Texas Tech (5,37)
Kentucky (11,45)
Arizona (12,28)
Maryland (23,6)
Purdue (7,55)
Michigan (39,13)
Ole Miss (24,21)
BYU (9,71)
Arkansas (65,17)

Check back for more stats, odds, updates and information you can bet on.

You can bet on it. 

FairwayJay is a proven sports handicapper and insightful analyst. He chips college basketball and additional sports betting coverage and reporting on industry news and events. Read more great insights from FairwayJay and follow him on  X: @FairwayJay