Biggest College Football Games Top 25 Week 10

The first Saturday of November kicks off a big month of college football 2025 Week 10 action. Top teams and leading contenders push towards conference titles, College Football Playoff spots and some of the biggest rivalry games. Tuesday, Nov. 4 is the first release of College Football Playoff rankings. The initial release won't include Penn State or Clemson, preseason top 5 teams and favorites to win the Big Ten and ACC and now both teams with losing records at 3-4 into November. 

No changes in the top 6 and three of those teams have a bye this week - Alabama, Georgia and Oregon. Ole Miss and Georgia Tech both won and swap spots and No. 7 and No. 8, and the Yellow Jackets are 8-0 for the first time since 1966. Vanderbilt won again to move up one spot to No. 9, and Miami and undefeated BYU are tied at No. 10 with BYU also on a bye this week.

Texas A&M remains undefeated in the SEC after a 49-25 road win at LSU, who fired coach Brian Kelly and leaves four top Power Four programs looking for new coaches along with Florida plus Penn State and UCLA in the Big Ten. In fact, six SEC teams went on the road and won on Oct. 25, and surprising top-10 Vanderbilt won at home and held off Missouri 17-10. The Commodores' 7-1 start is their best since 1941. 

Three Top 25 matchups for college football 2025 Week 10, and for the second straight week it includes Vanderbilt. The Commodores are just a 1-point underdog at Texas after opening Longhorns -2.5.

One noteable matchup that is not between Top 25 teams and has a huge line adjustment from preseason is Penn State at Ohio State. The Buckeyes are -20.5 point favorite, and the preseason line was Ohio State -4.5. It that isn't bad enough for the Nittany Lions, while also playing without their starting quarterback Drew Allar (broken ankle Oct. 11), Penn State has lost eight straight to Ohio State since 2017.

Top 25 Games and Week 10 Odds

Betting lines and college football odds from BetOnline and top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals. All times ET. Top 25 matchups in bold. 

Saturday, Nov. 1 

No. 1 Ohio State (-20.5) vs Penn State, 43 | 12 pm | FOX  
No. 2 Indiana (-21.5) at Maryland, 51.5 | 3:30 pm | CBS  
No. 3 Texas A&M | Bye
No. 4 Alabama | Bye
No. 5 Georgia (-7.5) vs. Florida, 50 (Jacksonville | 3:30 | ABC  
No. 6 Oregon | Bye
No. 7 Ole Miss (-12.5) vs South Carolina, 54.5 | 7 pm | ESPN  
No. 8 Georgia Tech (-5.5) at NC State, 57.5 | 7:30 pm | ESPN2
No. 9 Vanderbilt at No. 20 Texas (-1), 45 | 12 pm | ABC 
No. 10 Miami (-11.5) at SMU, 50.5 | 12 pm | ESPN
No. 10 BYU | Bye
No. 12 Notre Dame (-28.5) at Boston College, 58 | 3:30 pm| ESPN
No. 13 Texas Tech (-7.5) at Kansas State, 52.5 | 3:30 pm | FOX
No. 14 Tennessee (-3) vs. No. 18 Oklahoma, 57 | 7:30 pm | ABC
No. 15 Virginia (-3.5) at Cal, 54 | 3:45 pm | ESPN2
No. 16 Louisville (-10.5) at Virginia Tech, 54 | 3 pm | CW
No. 17 Cincinnati at No. 24 Utah (-7.5), 56.5 | 10:15 pm | ESPN
No. 19 Missouri | Bye 
No. 21 Michigan (-21) vs Purdue, 51 | 7 pm | Big Ten
No. 22 Houston (-14) vs West Virginia, 49 | 12 pm | FS1
No. 23 USC (-7) at Nebraska, 59 | 7:30 pm | NBC 
No. 25 Memphis (-14) at Rice, 49.5 | 7 pm  (Friday) | ESPN2 

Others receiving votes: Navy, Tulane, Washington, Iowa, South Florida, San Diego State, LSU, James Madison, North Texas, Illinois, Pittsburgh

Notable line moves from early Monday. 

- Texas from -2.5 to -1 vs Vandy & total 46.5 to 45
- Miami -11 to -11.5 at SMU
- Georgia Tech -6 to -5.5 at NC State
- Virginia -4 to -3.5 at Cal 

Other notable games on Sat., Nov. 1 

- Arizona State at Iowa State (-5.5), 50.5
- Mississippi State at Arkansas (-4.5), 57.5
- Navy at North Texas (-6), 65.5 

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NCAA Football Week 10 Top 25 Picks

Check back by Friday each week as we add more Picks and Opinions with select analysis, stats and any upgrades to support information you can bet on. Week 9 was no good, so we have some added work to do while also traveling this week.

Vanderbilt at Texas - Year to date stats show Vanderbilt (7-1/3-1 SEC) averaging 427 yards per game with a balanced offense (204 rush, 223 pass) to Texas' offense at 375/game (140 rush, 235 pass). The Longhorns (6-2/3-1) still have a dominant defense and the best defense Vanderbilt has faced with Texas allowing 300 yards per game (81 rush, 219 pass) at 4.2 yards per play. Vanderbilt's defense is still the best they have been in more than a decade allowing 350 ypg (110 rush, 240 pass) and 5.2 yards per play. Late Friday announcement is that QB Arch Manning (concussion) cleared protocol and will start. Opinion: Texas

Oklahoma at Tennessee - The Volunteers (6-2/3-2) will wear black helmets, black jerseys and black pants trimmed in orange when they tackle Oklahoma at Neyland Stadium. Tennessee is 4-1 in "dark mode" uniforms. The loser falls out of the College Football Playoff picture with a third loss. The top-5 Ole Miss offense (485/game) ran 87 plays against Oklahoma's previous No. 1 defense last week in a 34-25 road win. That could leave the Sooners defense more gassed while traveling to Tennessee. The Ole Miss Rebels piled up 431 yards but a modest 5.0 yards per play. Tennessee averages 481 yards per game to rank top-10 in the country (179 rush, 302 pass). Oklahoma's offense averages 359 per game (134 rush, 225 pass). The Sooners dominant, top defense fell out of the top few spots and allow 14 points per game, 253 ypg (80 rush, 173 pass) and tied with Ohio State for nation-low 3.7 yards per play defense. The Sooners hope to get a top LB back vs. Tennessee as both teams deal with injuries. The Volunteers defense allows 428 yards per game (147 rush, 281 pass) and 5.4 yards per play, and now may be without top CB Hood, who was injured vs. Kentucky. Following this game, Oklahoma has a bye and then hits the road to play Alabama before returning home to play Missouri and LSU. Sooners coach Brent Venables needs victories or he too will be on the firing line. Can the Sooners slow a Tennessee offense and 300 ypg pass attack that just scored 56 points at Kentucky? Vols QB Joey Aguilar was 20-of-26 passing for 396 yards and 3 TD's at an obscene 15.2 yards per pass with three receivers going over 100 yards. Tennessee won this matchup of top-15 teams last year 25-15 in Norman, and they'll beat Oklahoma again. Pick: Tennessee   

Cincinnati at Utah - The Utes 471 yards per game offense includes the top power conference rush attack averaging 266 yards per game. Utah's defense is also top 12 allowing just 294 yards per game (4.3 yards per play). Cincinnati's offense is 414 per game (186 rush, 228 pass), and the Bearcats defense allows 406 ypg and 5.5 yards per play. Opinion: Utah

You might be surprised to know that Ohio State and Alabama's top offensive lines have not paved the way for stronger rushing attacks. The Buckeyes average just 131 yards per game rushing and Alabama 119. LSU is at just 103 rushing yards per game and fired head coach Brian Kelly after getting blown out in the second half at home by Texas A&M.

Updates and added Picks and Opinions: 

Opinions 

SMU (+11.5) vs Miami
Maryland (+21.5) vs Indiana
Clemson (-3/3.5) vs Duke
Arkansas (-4.5) vs. Mississippi State
Auburn (-10/10.5) vs. Kentucky
USC at Nebraska - Over 59

Arkansas holds a +1.1 net yards per play differential in this matchup of all offense and no defense. Teams with +1.0 or greater net yppl diff as 'Dog to -7 went 7-1 ATS last week. High total 66 but high-scoring 'Hogs home win. 

Clemson line 2 TD's lower than start of season. Both teams off bye. Quarterback Klubnick returns for Tigers, who has the better defense by 6 points and 55 yards to slow the Blue Devils Air Raid offense. Clemson will be the first team to outgain Duke this season in victory to push towards a bowl.

Auburn projects to have a big double rushing edge (high ATS % situation) over Kentucky, who is winless in SEC play with the worst roster and little depth as they wear down in November. Auburn has been most competitive and some tough losses and the Tigers join Texas and Clemson as picks this week on teams with top defenses. 

Can the surging undefeated Hoosiers continue their dominating run? Just the third road game for Indiana, whose closest wins by 10 and 5 points were on the road. Coaching mismatch for certain, but Maryland led Washington on this field 20-3 in the fourth quarter before losing, to lead to a 3-game losing streak all by 4 points or less. The Terps 17.3 points per game defense vs. FBS foes ranks top-15 in the country. Indiana fits some very negative ATS profiles as an undefeated team in November, especially against a solid defensive team, .500 or greater team and with opponent coming off a loss - to add more value. 

SMU is at their best at home and rare big 'Dog role from recent seasons. Money coming in on Mustangs says plenty against a solid Miami side, but Hurricanes three toughest games were decided by 6 points or less including only loss to Louisville and SMU can still have a say in the ACC race at 3-1 with Miami 2-1 Recall SMU was a preseason contender after going 8-0 in ACC play last season and making the conference championship game. 

Picks and Opinions along with additional stats and insight to follow by Friday as you prepare for watch and wager college football action with added value betting at reduced juice sportsbooks. 

You can bet on it. 

FairwayJay is a proven sports handicapper and loves college football. He's been handicapping and betting college football for more than two decades and is recognized as one of the sports industry's most insightful analysts. He chips in additional sports betting coverage and reporting on industry news and events. Follow FairwayJay here at OSGA.com and on X  @FairwayJay for more sports and betting insights.